Permanent transformation

[Funksaw]

If a character gets hit with (specific special effect) they are forced to transform into (alternate form) permanently

I.E., if the Feng Shui Ascended get hit with Magic (rare in game world but frequently encountered in campaigns) they are forced to transform into animals permanently.

I.E., if a mutant gets hit with "The Cure" (rare in game world and also rare in campaigns) they are forced to lose their mutations - in often time removing disads like distinguishing features or blindness as well.

I.E., if a Twilight 2000 character gets hit with enough rads (common in game world and in campaigns), they are forced to transform into radiation poisoned soldier guy.

How is this modeled?

[Steve Long]

It's a Transform. You just have to define a "heal back" condition that's incredibly likely to occur (with the GM's permission, of course, but there's plenty of precedent for such things). Even in comics and gaming, "permanent" transformations aren't necessarily always as permanent as they sometimes appear... but that doesn't mean the heal back condition has to be common or likely.

In some situations, you could just model a permanent change to a character as a "radiation accident" -- i.e., an excuse to build a character with such-and-such powers, or a reason to spend Experience Points on new abilities. That might work for the T2K bit you mentioned.