Well, we've never done the "use whatever points you need", but our group did a 500-pt campaign (in 4th Ed, which is the equivalent of 600 or 700 points in 5th). I ran it and I used the Nexus (the infinite city) as a campaign setting. It worked ok, and was fairly amusing, but I think setting it in that city was the wrong idea. When you get up the big big points, the best thing you can do is to have a detailed background and to have memorable NPCs. And challenges. A regular city-based campaign probably isn't the best place to go for challenges. Something on the Big Stage, like world-encompassing or galaxy-spanning is the best idea.
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"I'm sick of chasing my dreams, man; I'm just gonna ask where they're going and hook up with them later." _Mitch Hedberg
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"In my experience, all the best plans end with the same five words ... 'and then, run like hell'."
-- Blues
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