Has anyone else ever done this one? I once ran a game centered around a group of "loser" heroes on about the level of Arthur from "The Tick." The characters included the likes of Ratman (with the ability to turn into a completely normal - if slightly more intelligent than usual - rat, and who was strong enough to - in his player's colorful terms - "lift a really, really fat guy!"), the Gamer (who threw different-shaped dice at people, and that was it), 2 Ton Mary (a librarian who was made of steel - literally - she only fit into the set because of her utter and complete lack of any skill relating to making the best use of her strength and toughness), and Mr. Nobody, whose only real ability was a minor Mind Control limited to suggesting bad ideas to people while being invisible. They battled the likes of Dairy Queen (a villain obsessed with dairy products and terribly inappropriate cross-dressing for his size and body type), The Sheepmaster (he could Mind Control sheep), and Magnudo (the former members of a Hispanic boy band who had magnetic powers), with their last climatic battle being against The Iconoclast, who impersonated a classic theme villain-types to confuse law enforcement and the heroes while he actually committed completely normal crimes like robbing a bank across town while the heroes were waiting at the location his thematic clues led them to. He also used a device called the Existential Quandrifier, that had a multipower that was randomly assigned each time he activated it.