My gaming group did a thought experiment setting for the aftermath of Feb 29 2012. We called it:
Dr. Destroyer saves the world!
Time line we came up with.
Feb 29 2012, Demon's ritual draws the majority of the high power supers into a fight with Demon Inner Circle. Vipers local nest become involved on the hero's side. Mechanion Takes control of Unity station and nukes the battle as it is in progress. All members of Demon die in the mystic backlash, most other mystic heroes/villains not involved in the fight also die from the backlash. Mechanion also nukes stronghold. The World Super Powers then launch their nukes at each other because Mechanion feeds them false intelligence on the source of the nuclear attacks. WWIII occurs. The USA, Russia, China and other 1 st & 2nd world nations suffer heavy losses from nuclear strikes. Most of the nukes headed to Europe are rerouted by Mechanion to hit major population centers in the 3rd world nations.
March 1, 2012 Mechanion's army of drones marches out of the north sea to conquer Europe. The population is enslaved to build factories that are designed. European Viper nests and Eurostar step up help defend with the European militarizes but get over run by the millions of drones.
June 1, 2012 After loosing Europe the remaining Viper leadership, plus elements of UNTIL and Primus, the Tiger Force and other Militarily groups agree to swear alligence to Dr. Destroyer. The first target is to retake/or destroy Unity Station as it has sunk most of the world navies and Dr Destroyer knows where a working teleport pad is.
Players would each make a super hero but most of the time an adventure party will consist of 1 super and a bunch of viper agents (or agents from another organization). We would rotate who super is leading a squad.