There are no ideas too stupid for a one-shot villain!
I've written up:
Bio-Degrader (Transform organic matter)
Intoxicant (Area Effect Drain INT can be killer!)
Mosquito, Master of Vampirism (yes, his costume looked like a certain mutant supremacist)
Pinball (an android composed of pinball machine parts, lots of EB with Bouncing attacks).
You know, even the best character concept can be explained so it sounds stupid. How much better is it to take a dumb concept and make it awesome?