Based On Con and Damage Reduction/Negation

[randian]

Are Based On Con attacks affected by all of the targets physical or energy defenses, including Damage Reduction and Damage Negation, or strictly by PD/ED?

[Steve Long]

The default rule, expressed in simplest terms, is this:  any defense that would protect a character against a Normal Damage attack against PD (or ED) also protects that character against a Based On CON atack against PD (or ED). But of course, the GM’s free to rule otherwise if he wishes.