I despise NPC's who are always, continually uncooperative in spite of PRE, Persuasion, Seduction and even appropriate situation. In one campaign I was in, you automatically knew that NPC cops would be hostile to the heroes, that NPC bartenders would be close-mouthed and suspicious, and that NPC bystanders would be afraid and mistrustful. No matter your reputation, your great deeds of valor, or your characteristics, this was just the tenor of the campain world.
And don't even mention NPC reporters...