Super-powered Fantasy (longish). The
I ran two Super Fantasy games a few years ago. Powered people in my setting could be mages, Talented, or Godlings. Mages are self-explanatory, Talented were magical mutants, and Godlings were semi-divine. Mage spells and Talented powers could be suppressed with Dispel Magic, Godling powers could not.
PCs were 75+75 characters (so I would get powered fantasy characters, not superheroes with chainmail) with an extra 50 points for skills or powers (so 200 points total).
Roughly 2000 years ago, the Elder Gods tried to destroy the world. They were stopped by their children (the Young Gods) and a vast army of mortals. The only survivors were the New Gods (children of the Young Gods) and some mortals. The New Gods stuck around for a while helping recreate civilization, and mating with a few worthy mortals.
In the present, the Godlings have lost the last of their Divine Aspect, but retain some of their Divine Attributes. In some isolated villages, they are still worshipped.
In most countries, the powerful families had co-opted the mages, Talented, and Godlings by marrying them.
The token monotheistic religious fanatic country persecuted Godlings because their powers were non-magical in origin, and everyone knows that magic is the Gift of The One True God. The Godling rebels in this country were Balor (He of the Fiery Eye) and his Merry Men, obvious X-Men knockoffs. My GMNPC was the martial artist/ranger son of Mace, the Merry Men's metal-bodied brick.
A southern desert city hired a group of powered people (all three types) as a shield against raids from desert nomads (JLA knockoffs).
The various PCs included an elven thief with laser and light powers, a human ranger with enhanced senses, a human super-soldier military man, human elemental mage/swordsman, human earth elementalist, etc.
The world had recently started a magical tech renaissance, so normals with enough magical weaponry could go toe-to-toe with powered people.
The game unfortunately ended before the final act, which would have revealed the true history of the world and how magic, the Talented, and Godlings worked.
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I won't go into the cosmology of this world, but the Godlings were the descendents of the New Gods, a superhero team stranded on this world during an apocalyptic battle between the original high-tech settlers of this world (remembered as the Elder Gods) and their primitive descendants.