OK, this is for action movie fans, 80s nostalgic:
Remember the film "Highlander"? The first, the good one. Well, imagine The Kurgan killed McLeod and won The Prize.
Now the villain has new powers and can rule the world, but there are some heroes in his path to power, heroes from this 80s movies we all love. And they will be the Player Characters, of course. Well, or may be not the same characters as McClane, Riggs, Rambo, Danko but based on this archetypes. I have a real difficult time to find action girls, though.
The Prize may be some kind of Telepathy powers and limited Mind Control, apart from his strenght and skill boosted from the Quickenings. He can recruit lots of minions and lieutenants from the movies, or generic villains. He remains an immortal and can only be defeated by beheading.
Kurgan knows who will fight against him (is a bit in touch with everyone's mind, like McLeod at the end of the flick, planetary Mind Scan?), so the first adventure could unite the PCs against the attempted assassination of them all.
Minion ideas: The New World cult from "Cobra".
Let the fun and homage begin.