Re: PRE Drains
It's expensive as hell, but I think this would be a good build for a Mind Flayer-like Mental Blast power:
150 Lay Waste to Your Mind: 3d6 DEX, INT, EGO, and PRE Drain, Four Characteristics Simultaneously (+1), Based on Ego Combat Value (Vs. Mental
Defense; +1), Range (Limited Range 20"; +1/4), Reduced Endurance (1/2 END; +1/4), Points Return at the Rate of 5 per Week (+1 1/2)