If you're a popular superhero, make sure there is a revolving door installed in your coffin since you can never really die. If you're a popular villain, make certain to be buried in a teleportation pod with no houseflies.
Dwarves. Always played them in Pathfinder.
Elves. They remind me too much of the Thalmor from Skyrim which is why my characters always kill them on sight.
DC'S Black Mask or The Kingpin?
The first thing any semi competent government agency should do in finding and recruiting people with is get at least one person who can nullify other's powers like The Haitian from Heroes.
A viral bioweapon like nanites programmed to render the human race infertile has already been done.
Sending out a satellite into deep space and have the satellite fire a powerful energy beam directly at the sun in order to trigger a massive solar flare to evaporate the entire ozone layer of Earth.