Re: Flash on 350 points
Physical Limitation: Needs Extra Food is an obvious one: the Flash burns up so much energy even at rest that he has to eat an enormous amount to avoid crippling fatigue. We're talking Michael Phelps levels of consumption multiplied by a factor of about three.
The most obvious disad for the Flash, of course, is Hunted: Rogue's Gallery. The Flash's foes are a colorful lot, and join forces frequently (even socializing together). Guys like Captain Cold, The Trickster, Captain Boomerang and Mirror Master are much more formidable than they would appear at first glance. Individually most are less powerful than he is, using gadgetry rather than inborn superpowers, but together they are As Powerful (especially given their tendency to appear two or three at a time).