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I was just starting a campaign that was kind of dealing with this. Most large cities have a taskforce dedicated to supervillains, whether at the street level or more. This specialized unit often employ a few superhumans to help offset the their odds a bit. In the campaign I've been working on, the city has been a bit overpowered by villains and gangs. So they sponsor a hero team that works exclusively with the police to help protect the city. Local police powers, access to the police database, and a crash course on law enforcement are the basics that everyone gets, and they answer to a special liaison officer that answers to the police commissioner. What kind of threats do they handle? Pretty much anything the city may throw at them. From villains akin to Spider-Man's rogues, to juiced up gangs, to Kingpins and gang wars, to the occasional Magneto attack. 
 
I agree that, in most cases, setting a street level tone would be my normal go-to for such a game. But I'm trying something different to see how it evolves. 

Okay, here is where Strike Force Organizations stands:
 
I have completed and uploaded to a Google Drive the following: ARL, the Blood, the Circle, the Wanderers, and the Cult of the Beast. Cult of the Beast expands on the material in Aaron Allston's Strike Force. It is 3200 words, mostly detailing the Cult's organization. It includes one sample magic item and a single NPC. Next up is Carousel/Families/Reapers. I will repeat the Background for Alasdar Dell as that is the origin of the Families. The rest of this section will probably be all character sheets of different Families members. Last will be Yoosoo. This will be a fairly complete entry, as Aaron did write a background and I have a lot of character sheets to work with. The cast is pretty much the same as what was seen in Ninja Hero 4e (I think). I may consider the Hell Raisers, which is Denier's supervillain team. I'd need to talk to Jason Walters to see what he says.

Also (after a senior/derp moment on my side):

If you have Cost Multipliers enabled under Campaign Rules, you can set a Cost Multiplier of 0 on either the individual Complications or on a List (it will apply to all items added to the List).
 
I was actually poring through the code to figure out where I had disabled the Cost Multiplier button for Complications...it took me WAY too long to realize that I had done no such thing and simply had them disabled under the Campaign Rules.

I'm sure Bats would do just fine against Spidey's foes, but it also depends on who's writing him. 

Spidey’s rogues gallery started with low-pointed builds but most of them have been saving up their XPs over the years.
 
If you treated Spider-Man’s career as a solo Champions campaign, or maybe one where other players play the various villains and occasional team-up heroes, the internal clock in that campaign has been ticking away around 10+ years, and the external clock for several decades more. That represents a lot of table time, so even a stingy GM would have given Peter’s player (and those who keep reoccurring in his rogues gallery) hundreds of xps by now.

Exactly my thought. Spidey's rogues gallery is exceptional. Biggest difference between the Spider's villains and the Bat's is that most of the former's enemies are actual superhumans, while the latter's are mostly normal human psychopaths with some gimmick. I'm not sure how long Batman would last if he had the likes of Kraven, Rhino, and Sandman regularly coming after him. OTOH Green Goblin, Mysterio, or Kingpin would make splendid Bat-villains, while Clayface, Mr. Freeze, or Man-Bat would work great against the Webhead. And of course they both essentially share a female cat-themed frenemy.

Early Spider-Man is definitely a teen hero IMHO, and a great example of progression from teen to regular hero over the years. In fact, when I had players complain about the 250pt heroes of yester-Champions, Spidey was my usual example of why they only had 250pts. 
 
As for his rogue's gallery, I've always been a fan. You get legendary bad guys like Green Goblin or Doctor Octopus, and then you get chumps like Grizzly or Kangaroo. Easily one of the best groups of villains in comics (and tied with Batman and Flash in my mind).

Early Spider-Man is definitely a teen hero IMHO, and a great example of progression from teen to regular hero over the years. In fact, when I had players complain about the 250pt heroes of yester-Champions, Spidey was my usual example of why they only had 250pts. 
 
As for his rogue's gallery, I've always been a fan. You get legendary bad guys like Green Goblin or Doctor Octopus, and then you get chumps like Grizzly or Kangaroo. Easily one of the best groups of villains in comics (and tied with Batman and Flash in my mind).

Early Spider-Man is definitely a teen hero IMHO, and a great example of progression from teen to regular hero over the years. In fact, when I had players complain about the 250pt heroes of yester-Champions, Spidey was my usual example of why they only had 250pts. 
 
As for his rogue's gallery, I've always been a fan. You get legendary bad guys like Green Goblin or Doctor Octopus, and then you get chumps like Grizzly or Kangaroo. Easily one of the best groups of villains in comics (and tied with Batman and Flash in my mind).

An update on Strike Force Organizations. Okay, so, let's be honest, I worked on Aaron Allston's Strike Force eight years ago. So, when I excitedly laid out my idea list of expanded organizations, I TOTALLY forgot I had put the Cult of the Beast into Aaron Allston's Strike Force. And looking over what there was left made me decide there was no point. So I have moved on the the Families. The issue I now face is that there is no real origin for them -- the Background/History for Alasdar Dell's entry in AASF pretty much sums up how the Families came to be. I am thinking I will repeat Alasdar's origin, and use that to set the stage for the six character sheets I have -- other members of the Families and some of their superhuman agents. Now, when it comes to Yooso, I have an update origin for the group, updated character sheets, and other material, so this will proceed as planned.

Without modifying the template, the following options would work (either manually on each character or as a prefab):
 
1. Custom "Adder" on each Complication to negate the cost - the custom Adder needs a negative cost greater than or equal to the cost of the Complication -- all Complications have a minimum of 0, so you won't get points back if the Adder is too much.
 
2. Create a List on the Complications tab and add a Private Adder to it.  Set the value of the private Adder to the total of all Package Complications (e.g. -175 points).  Add all Package Complications to the list.  Math involved in this approach, as Lists don't have the same minimum value as Complications (hence the Private Adder).

I had to revise this as I forgot an Advantage. But you get the scale of Aaron's take on cosmic supers.

A sneak peak at the Wanderers portion of Strike Force Organizations: Transportation 50,000 Light Years Away: Teleportation 1m, x8,192 Increased Mass, MegaScale (1m = 50,000 lightyears; +5 1/2), Cannot Alter Scale (-1/4) (412 Active Points); Extra Time (1 Turn; -1 1/4), Linked (Gravitational Attraction Field;; -1/4), Side Effects (Götterdämmerung enters an extended coma lasting months to years; -2). Total cost: 91 points.

Update for those following the Strike Force Organizations progress: the Wanderers are at ~24,000 words. I need to add the Campaign Use and Scenario sections, edit the character sheets a bit, fix some errors, and do some formatting. I hope to have this section done by the end of the week or so.

You're talking about impacts to the player and to the campaign...not to the character.  
 
I'll also note that this is MicroLad hijacking the entire game, should you do it.  Not that it's wrong per se, but that's the impact, and that's something I grew very leery about a long time ago.  It's also part of the reason why I agree with RavenX99...especially with an NPC, this'd become just a plot device.  And yes, with an NPC, points are NOT a primary concern.

I would be ambivalent about it.  It would be an opportunity - bluebooking the Microverse, it would be a mini-series in a comic book, not a trauma event.
 
If me and the player had discussed it, and nothing like this should be done without that kind of discussion, then it is relatively minor.  I would have the player pull out a pre-prepared alternate PC for the duration.  I would pull out the pre-prepared scenario about finding MicroLad.
 
It would shake things up a bit.
 
With an NPC then it is even less so.
 
All in my incredibly humble opinion, of course.
 
Doc

You're trying to make a points analysis, rather than a character impact analysis.
 
If this was a PC, getting taken out of the campaign for a month, would you not say this was *incredibly* extreme?
 
How is this any different from being captured, in any meaningful way???  The impact is that the person cannot interact with the world *at all* while this is the case.  So...microverse or a prison cell, who cares?  That's a meaningless distinction.

There is no reason Accidental Change cannot cause the character to change into a form that is so small it does not exist in our universe.  The only difference between this and shrinking down to 1 inch is size.  Making it fully impairing means the character is out of the game until the character changes back.  
 
The complication has an offsetting advantage that reduces the value of the complication.  While the complication takes the character out of the game for a while it also prevents him from being captured. If this was under the control of the character it would have to be bought instead of being a complication.   As long as the character occasionally has need to shrink down to this size it can still cause problems so is a valid complication.  
 

Accidental Change doesn't rip a character out of the world for a few weeks.  That feels like a pretty huge complication, and I don't feel the two axes of Physical Complication really reflect the severity because it doesn't really consider how _long_ the complication is affecting.  It's the same points for a PhysComp that knocks you out for 5 minutes.
you lose the fight you're out of the "adventure"... your immediate plans are disrupted you're just "gone" for 1-6 weeks... short-term plans are disrupted, you have to make excuses to everyone about where you were, you could lose your day job, etc. Hm.  But these also feel like the same results of being knocked out for 5 minutes, leading to being captured and detained. 🤔
As a GM, I'd be really reluctant to put this kind of thing on an NPC, unless I planned to never actually roll for that 8- and just declared it happened as a plot device where I found it useful to the story.
But also, it's an NPC, so points aren't really important here, unless you're writing for publication.
 

If you are using the physical limitation you should apply the limitation requires a roll to reduce the value of the complication.  The complication should not be worth as much as one that always affects the character at the same frequency.  As it stands the complication is worth 20 points.  Shrinking is only 6 points so the character can easily purchase 1 extra level that is rarely used.  
 
Accidental Change already takes this into consideration. The value of the accidental change is 5 points for uncommon or 10 points for common.  That seems more appropriate for this.  
 

Some interesting ideas overall, folks. I agree with Doc about the paying points bit. All three of these solutions are pretty cool and have given me something to think about. Didn't even think about using Accidental Change. 

Extreme Physical Limitation.  Wrote up this one:
 
Phys. Lim.:  When fully shrunk, 8- to fall into the microverse for 1d6 weeks (Infrequently; Fully Impairing)
 
Or, alternately, Extreme Side Effect.  Extreme starts at -1.  If it always happened, it'd go to -2.  OK, so for something intermediate...happens on an 8- might be another -1/4, 11- another -1/2.  You're saying the NPC's power simply does this sometimes, and he's got no control...so I'm taking the additional -1 for "it always happens" and reducing it based on how often it happens.
 
 

I would use Accidental Change for this.  Depending on how often he shrinks down to the dangerous size it would be worth about 5-10 point on an 8 or less roll.  The change is that he goes to the other universe.

@Grailknight has made a good suggestion but it feels off to me if the NPC has to pay points for something that complicates their life or disadvantages them.
 
I would be more inclined to make it a custom complication.  It might be a small value one, maybe five points, when using full shrinking, on an 8 or less he gets trapped in the Microverse for 1D6 weeks.

No Conscous Control XDM with burnout