I started my heroes off as Competent Normals, scientists all. And we ran thru for about a year with them as the normals. The player base had 3 experienced Hero Games players (although we hadn't run Champions in about 8 or more years), 4 who had played other RPG's (mostly DnD) and one who had never played an RPG at all.
The first year was a refresher for all of us on how the system ran, learning the basics, and moving forward. I ran a couple Adventurer's Club scenarios (broken down so they wouldn't die) to familiarize them with combat, skill rolls, and some combat maneuvers. Now they have powers and are learning the higher end of combat with damage etc.
It has been a lengthy process, and our games are quite Role Play interactive, but everyone seems to be enjoying the time! Now they are figuring out their powers and how they will interact with the rest of the world... (duh, duh, duh)!!