So, a gaming buddy of mine just mentioned to me that she'd be interested in playing a game where the PCs are (or can be) starships, citing Anne McCaffery's "The Ship Who Sang" as a reference. I'm rather intrigued by the idea, as I've read plenty of stories with characters who are no longer, or never were, quite human, and I've done a bit of my own thinking about what a person could be if they didn't have to pass for a greasy Mark 1 Mod 0 homo sapiens sapiens.
Therefore, I'm starting a thread here to ask for information, advice, and random thoughts on the matter. Has anyone here ever run a game with such a concept, or given serious thought to it? Are there any books/stories/movies/webcomics that I should definitely read if I'm going to run such a game? Any more-or-less on-topic thoughts you might have are welcome here.